Abstract: Facing the challenge of digitization, with decreasing the moving distance among different screens for the same operator as goal, and taking accident procedures of digital human-computer interface in Nuclear Power Plant as a research object and human reliability as basis, a shortest moving path algorithm with dynamic flag for accident procedure layout is proposed and the reliability executing process analyzed by neural networks human reliability evaluation method. Finally, the proposed method is analyzed by an example. The experiment shows that the proposed method has good performance and could solve the procedure automatic layout in accident among the screens.