Abstract: With the rapidly growing demands of hazardous chemical materials, transport accidents are more and more frequent. In order to reduce the risk of transportation and ensure the transportation safety, a research is conducted by connecting scheduling problems of hazardous chemical materials with multimodal transportation and the hazardous chemical materials packed in tank containers. A multimodal transportation scheduling model of hazardous chemical materials in tank containers is established based on the minimum cost and risk under a time constraint. At the same time, a fuzzy algorithm based on two-dimensional Euclidean distance is used to solve the model. The case study verifies that the application of multimodal transport to scheduling problem of hazardous chemical materials is beneficial to reduce risks and ensure safety of the scheduling. In addition, this method can reach the goal of minimizing cost within the scope of the controllable risk and it is a good reference for the logistics enterprise to do scheduling plan.