Abstract: To improve the efficiency of human resources used in the project, an optimization method of assigning multi-skilled human resources and scheduling projects is put forward. First of all, with a heuristic algorithm presented to level the human resources, a scheduling scheme with low peak in human resource requirement can be obtained. Then, based on the determined scheme, the overlapping relationships between activities are identified and converted to a series of effective constraints to assigning multi-skilled human resources. Finally, an integer programming model is established and calculated by programming. The research results show that the method can be used to quickly find a near optimal solution of the problem, using less human resource to complete the tasks, and reduce the cost of human resources effectively.