Abstract: Prevalent muscoloskeletal disorders among the plane's fuselage assembly workers in Southwest China are described and investigated, with the primary goal of assessing the ergonomic level of the the plane's fuselage assembly line. The worker's recall and the cross sectional observation methods are used in research, as well as the the Nordic Standardized Questionnaire and Quick Exposure of Check(QEC)tool. And the data are tackled using SPSS19.0, p＜0.05 to judge the significant differences. 61 workers are interviewed individually. Out of every 10 workers, in the last 12 months, 9 reported complaints in at least one investigated area in the body. The QEC scores show that the neck part (16.86±1.328) and wrist part (42.58±4.931) are in very high ergonomic level. The results suggest that preventive measures such as vocational training, new work techniques, and new work organization with job rotation and active rest and breaks are recommended.