Abstract: An idea of alleviating the adverse effects of crowd congestion on tour activity is proposed from the perspectives of optimizing the layout of a tour activity place. The internal correlation between the distribution of attractions and resources is studied. By introducing Moran's I from spatial statistics, an optimization model of the layout of tour activity place is established with bi-objective. Then, an ant colony optimization approach is proposed. Test instance demonstrates that the algorithm can be used to solve the above problem effectively.