Abstract: Error proofing design for controls in aircraft cockpit is one of the design goals of ergonomics. Based on error proofing design methods, the differences and similarities between Boeing and Airbus aircraft are studied by analyzing questionnaire data. By analysis of variance, the reasons for the different efforts of error proofing design methods between Boeing and Airbus aircraft are further studied. The analysis is divided into two parts: the degree of security support and the rate of recurrence. The effects of age, driving experience, technician grade on the same error proofing method are considered. The result shows that Boeing design has a superior maneuverability and Airbus design stresses on logical protection. With the growing of age and driving experience, the frequency of operating error has different trend for different controls. The research provides a reference for the study of error proofing methods in the cockpit.