Abstract: The innovation chain from research to market can be divided into three stages. With innovation failure-related factors such as structure obstacles, process obstacles, market obstacles and other variables considered, technological innovation process obstacles causing innovation failures are analyzed. Research shows that technological innovation failures mainly occur in the early stage of the technical innovation. In terms of impact, the impact of product innovation obstacle is in a large area, and market structure obstacle and process innovation obstacle are in a small area. Product platform, engineering ability and difference in product market are the key factors causing our country's enterprise technological innovation failures.